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In 1850, California became part of the United States following the Mexican–American War and the admission of California to the union.
The city is the seat of San Diego County and is the economic center of the region as well as the San Diego–Tijuana metropolitan area.
In November 1602, Sebastián Vizcaíno was sent to map the California coast.
Arriving on his flagship San Diego, Vizcaíno surveyed the harbor and what are now Mission Bay and Point Loma and named the area for the Catholic Saint Didacus, a Spaniard more commonly known as San Diego de Alcalá.
The city is known for its mild year-round climate, natural deep-water harbor, extensive beaches, long association with the United States Navy, and recent emergence as a healthcare and biotechnology development center.
San Diego has been called "the birthplace of California".
Historically home to the Kumeyaay people, it was the first site visited by Europeans on what is now the West Coast of the United States.
It is part of the San Diego–Tijuana conurbation, the second-largest transborder agglomeration between the US and a bordering country after Detroit–Windsor, with a population of 4,922,723 people.
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San Diego's main economic engines are military and defense-related activities, tourism, international trade, and manufacturing.
The presence of the University of California, San Diego (UCSD), with the affiliated UCSD Medical Center, has helped make the area a center of research in biotechnology.